國家衛生研究院 NHRI:Item 3990099045/11625
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    题名: Dendritic cell-derived exosomes increase the efficacy of anti-PD-L1 antibody in melanoma model
    作者: Chao, PK;Hsu, TA
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Immunotherapy is a promising treatment for metastatic melanoma. However, treatment of melanoma with an immune checkpoint inhibitor, such as anti-PD-L1 antibody, has lower response rate in patients. Dendritic cells play a critical role as central orchestrators of the immune response. Dendritic cell-derived exosomes might inherit some special functions from dendritic cells and exert these functions in vivo. We find that microRNAs and proteins are present in dendritic cell-derived exosomes and could affect other immature dendritic cells. Then, we induced melanomas in C57BL/6 mice and then intravenously injected dendritic cell-derived exosomes into mice, observing that the combination of dendritic cell-derived exosomes enhanced the efficacy of anti-PD-L1 antibody, but treatment with either dendritic cell-derived exosomes or anti-PD-L1 antibody alone, did not. These were suggested that combination of dendritic cell-derived exosomes and anti-PD-L1 antibody will significantly improve overall survival time.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):1322.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773606228
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