國家衛生研究院 NHRI:Item 3990099045/11626
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    题名: Establishment and characterization of novel syngeneic oral squamous cell carcinoma mouse cell lines
    作者: Chen, YW;Chuang, TH;Liu, KJ;Yen, YC;Wang, SH;Kuo, CC
    贡献者: Institute of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research;Immunology Research Center
    摘要: M1-2 and M2-3 cells were established from mouse tongue tumor specimens induced by 4-NQO and arecoline. M1-2 and M2-3 cells partially developed tumors after subcutaneous injection in immune-compromised mice. In contrast, M1-2 and M2-3 cells failed to develop any tumor by orthotopic inoculation of syngeneic mice. By in vitro selection, M1-2sph and M2-3sph cells were established and only M1-2sph cells successfully developed tumors in syngeneic mice. M1-2sph and M2-3sph cells showed the higher activities of cell growth and sphere formation than their parental cells. The higher Klf4 and Nanog expression was detected only in M1-2sph cells. M1-2sph and M2-3sph cells showed the higher capabilities of migration and invasion than their parental cells. The epithelial mesenchymal transition (EMT) was occurred only in M1-2sph cells. The higher Twist and Slug expression was detected only in M1-2sph cells. The profiling of p ERK1/2 activation was changed between M1-2 and M1-2sph cells but not between M2-3 and M2-3sph cells. The relationship between ERK1/2 activation and occurrence of EMT and sphere formation was under investigation.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):386.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601339
    显示于类别:[郭靜娟] 會議論文/會議摘要
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