國家衛生研究院 NHRI:Item 3990099045/11628
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 908638      Online Users : 1038
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11628


    Title: Ubiquitin specific protease 4 regulates lung cancer progression by control of inflammation and stemness
    Authors: Lai, CY;Yeh, DW;Lu, CH;Liu, YL;Chuang, TH
    Contributors: Immunology Research Center
    Abstract: Ubiquitination and deubiquitination are important posttranslational modifications involved in various cellular processes. To investigate the role of deubiquitinase (DUBs) in lung cancer progression, we analyzed correlation of DUB expression with survival data in a database linking TCGA survival data to gene expression. We found that low expression of ubiquitin specific protease 4 (USP4) was associated with low survival rate of lung cancer patients. Moreover, USP4 was downregulated in stemness enriched cancers. Thus, the effect of USP4 downregulation on tumor propagation in lung cancers were evaluated. Knockdown of USP4 in lung cancers enhanced NF-&kappaB activation and inflammatory responses. In addition, the capability of sphere formation and expression of stemness associated genes were elevated in USP4 knockdown cells. Further, knockdown of USP4 enhanced proliferation and expression molecule for resistant to immune therapy in lung cancers as well as enhanced resistance to chemotherapy drugs. Animal studies showed that reduction of USP4 expression in lung cancers enhanced tumor growth and increased inflammatory and stemness properties in tumors.
    Date: 2018-12
    Relation: Cancer Science. 2018 Dec;109(Suppl. 2):1231.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773606046
    Appears in Collections:[Tsung-Hsien Chuang] Conference Papers/Meeting Abstract

    Files in This Item:

    File SizeFormat
    ISI000453773606046.pdf31KbAdobe PDF248View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback