國家衛生研究院 NHRI:Item 3990099045/11631
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 852941      Online Users : 472
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11631


    Title: Pharmacokinetic study of amoxicillin in Japanese eel Anguilla japonica by high performance liquid chromatography with fluorescence detection
    Authors: Hung, YW;Lin, YH;Chan, CY;Wang, WS;Chiu, CF;Chiu, CC;Chiu, HW;Tsai, WH;Hung, SW
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Amoxicillin (AMX) is widely used for the treatment of gastrointestinal and systemic infections. AMX residues above certain levels may pose a threat to human health. Therefore, this study aimed to understand the pharmacokinetics of AMX in Japanese eel, Anguilla japonica, using high-performance liquid chromatography (HPLC) with fluorescence detection. Japanese eels were treated with AMX at concentrations of 40 or 80 mg kg−1 body weight (BW) daily via oral administration. The results revealed that the recoveries of AMX from the muscle, liver, and sera of eels were 84.7–105.1%, 81.8–104.9%, and 88.6–106.3%, respectively. The observed peak retention time was approximately 4.2 min. After administration of 40 mg kg−1 BW per day of AMX, the pharmacokinetic parameters were detected, respectively. The average drug residue concentration in muscles was 180 and 260 ng mL−1 on day 1 and day 2, respectively, and in the liver, it was 70 and 110 ng mL−1 on day 1 and day 2, respectively, after the 40 mg kg−1 BW daily AMX administration. Residue concentrations in the muscle and liver on day 3 after 40 mg kg−1 BW administrations were below the limit of detection (<30 ng mL−1). On the other hand, the average drug residue concentration in muscles was 930 and 1070 ng mL−1 on day 1 and day 3, respectively, and in the liver, it was 35 and 95 ng mL−1 on day 1 and day 3, respectively, after 80 mg kg−1 BW AMX administration. However, the residue concentrations in the muscle and liver on day 5 after 80 mg kg−1 BW administration were below the detection limit (<30 ng mL−1). The pharmacokinetic information derived from Japanese eel can be used to design rational dosing regimens and can also assist the Taiwan government in formulating laws and regulations for AMX residues in Japanese eels. Additionally, this information will provide greater protection to consumers of aquaculture products.
    Date: 2019-03
    Relation: Aquaculture Reports. 2019 Mar;13:Article number 100184.
    Link to: http://dx.doi.org/10.1016/j.aqrep.2019.100184
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2352-5134&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000460603900012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85060336349
    Appears in Collections:[Others] Periodical Articles

    Files in This Item:

    File SizeFormat
    SCP85060336349.pdf1065KbAdobe PDF368View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback