國家衛生研究院 NHRI:Item 3990099045/11638
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 909744      在线人数 : 849
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11638


    题名: Caffeic Acid Phenethyl Ester (CAPE) suppresses protein expression level of AR-V7 in human prostate cancer
    作者: Kuo, YY;Chang, CR;Chuu, CP
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Androgen receptor splice variant-7 (AR-V7), an androgen-insensitive transcription factor, plays an essential role in the development of castration-resistant prostate cancer (CRPC). Enzalutamide and abiraterone can not efficiently inhibit CRPC with AR-V7 expression. Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. We previously reported that CAPE treatment suppresses cell proliferation and tumor metastasis of prostate cancer cells. We thus examined if CAPE treatment can reduce expression of AR-V7. AR-V7 variant is highly expressed in 22RV1 cell line. We observed that CAPE treatment suppressed both mRNA and protein expression of AR-V7 as well as its downstream ubiquitin-conjugating enzyme 2C (UBE2C) in 22RV1 cell line. Protein stability of AR-V7 is affected by the phosphorylation of Serine 81 on AR, which is regulated by CDK1. Our data showed that CAPE reduced protein expression of CDK1 and accelerated degradation of AR-V7. In xenograft model, we observed CAPE treatment repressed tumor growth and angiogenesis of 22RV1 as well as suppressed expression of AR-V7. Our data suggested that CAPE might be a potential therapy for CRPC.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):995.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773604378
    显示于类别:[褚志斌] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000453773604378.pdf39KbAdobe PDF253检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈