國家衛生研究院 NHRI:Item 3990099045/11649
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    题名: Molecular epidemiology of emerging carbapenem resistance in acinetobacter nosocomialis and acinetobacter pittii in Taiwan, 2010-2014
    作者: Chen, FJ;Huang, WC;Liao, YC;Wang, HY;Lai, JF;Kuo, SC;Lauderdale, TL;Sytwu, HK
    贡献者: National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences
    摘要: This study investigated the molecular epidemiology of carbapenem-resistant Acinetobacter nosocomialis and Acinetobacter pittii (ANAP). Clinical isolates of Acinetobacter spp. collected by the biennial nationwide Taiwan Surveillance of Antimicrobial Resistance program from 2010-2014 were subjected to species identification, antimicrobial susceptibility testing, and PCR for detection of carbapenemase genes. Whole genome sequencing or PCR mapping was performed to study the genetic surroundings of the carbapenemase genes. Among 1041 Acinetobacter isolates, the proportion of ANAP increased from 11% in 2010 to 22% in 2014. The rate of carbapenem resistance in these isolates increased from 7.5% (3/40) to 22% (14/64), with a concomitant increase in their resistance to other antibiotics. The bla OXA-72 and bla OXA-58 genes were highly prevalent in carbapenem-resistant ANAP. Various genetic structures were found upstream of bla OXA-58 in different plasmids. Among the plasmids found to contain bla OXA-72 flanked by XerC/XerD, pAB-NCGM253-like was identified in 8 of 10 isolates. Conjugations of plasmids carrying bla OXA-72 or bla OXA-58 to A. baumannii were successful. In addition, three isolates with chromosome-located bla OXA-23 embedded in AbGRI1-type structure with disruption of genes other than comM were detected. Two highly similar plasmids carrying class I integron containing bla IMP-1 and aminoglycoside resistance genes were also found. The universal presence of bla OXA-272/213-like on A. pittii chromosomes and their lack of contribution to carbapenem resistance indicate its potential to be a marker for species identification. The increase of ANAP along with their diverse mechanisms of carbapenem resistance may herald their further spread and warrants close monitoring.
    日期: 2019-04
    關聯: Antimicrobial Agents and Chemotherapy. 2019 Apr;63(4):e02007-18.
    Link to: http://dx.doi.org/10.1128/aac.02007-18
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000462474100024
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85063693792
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