國家衛生研究院 NHRI:Item 3990099045/1165
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    題名: Antiviral drug discovery targeting to viral proteases
    作者: Hsu, JTA;Wang, HC;Chen, GW;Shih, SR
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Proteases fulfill multiple roles in health and disease, and considerable interest has been expressed in the design and development of synthetic inhibitors of disease-related proteases. Virus-encoded proteases have been shown to be involved in the replication of many viruses. The success of anti-HIV-1 therapy using specific and potent protease inhibitors suggests that viral proteases can be the valid molecular targets for the development of antiviral drugs against other viruses. Intensive genetic and biochemical studies have been conducted on viral proteases and new insights and results are rapidly emerging. This work reviews features of viral proteases with respective to the development of effective antiviral therapy.
    關鍵詞: Pharmacology & Pharmacy
    日期: 2006
    關聯: Current Pharmaceutical Design. 2006;12(11):1301-1314.
    Link to: http://dx.doi.org/10.2174/138161206776361110
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1381-6128&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000237432600002
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33744988629
    顯示於類別:[徐祖安] 期刊論文

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