國家衛生研究院 NHRI:Item 3990099045/11667
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11667


    Title: Vegetable signatures derived from human urinary metabolomic data in controlled feeding studies
    Authors: Lynn, KS;Cheng, ML;Yang, HC;Liang, YJ;Kang, MJ;Chen, FL;Shiao, MS;Pan, WH
    Contributors: Institute of Population Health Sciences
    Abstract: Examination of changes in urinary metabolomic profiles after vegetable ingestion may lead to new methods of assessing plant food intake. To this regard, we developed a proof-of-principle methodology to identify urinary metabolomic signatures for spinach, celery, and onion. Three feeding studies were conducted. In the first study, healthy individuals were fed with spinach, celery, onion, and no vegetables in four separate experiments with pooled urinary samples for metabolite discovery. The same protocol was used to validate the finding at the individual level in the second study and when feeding all three vegetables simultaneously in the third study. An LC-MS-based metabolomics approach was adopted to search for indicative metabolites from urine samples collected during multiple time periods before and after the meal. Consequently, a total of 1, 9, and 3 nonoverlapping urinary metabolites were associated with the intake of spinach, celery, and onion, respectively. The PCA signature of these metabolites followed a similar "time cycle" pattern, which maximized at approximately 2-4 h after intake. In addition, the metabolite profiles for the same vegetable were consistent across samples, regardless of whether it was consumed individually or in combination. The developed methodology along with the identified urinary metabolomic signatures were potential tools for assessing plant food intake.
    Date: 2019-01
    Relation: Journal of Proteome Research. 2019 Jan;18(1):159-168.
    Link to: http://dx.doi.org/10.1021/acs.jproteome.8b00470
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1535-3893&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000455285900014
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85059555604
    Appears in Collections:[Wen-Harn Pan] Periodical Articles

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