國家衛生研究院 NHRI:Item 3990099045/1168
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    题名: Formulation, stability, and delivery of live attenuated vaccines for human use
    作者: Burke, CJ;Hsu, TA;Volkin, DB
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: The successful use of live attenuated viral and bacterial vaccines depends not only on the proper choice and delivery of the microorganisms, but also on maintaining the sufficient potency required for an immune response. The inherent lability of live organisms presents a particular formulation challenge in terms of stabilizing and preserving vaccine viability during manufacturing, storage, and administration. This review examines pharmaceutical approaches to the stabilization, formulation, and lyophilization of biological macromolecules in general, as well as the specific applicability of these principles to live attenuated viral and bacterial vaccines . Several formulation development case studies with live vaccines are presented. In addition, comparative stability data are summarized for many other live viral and bacterial preparations. Various pharmaceutical issues with conventional and novel delivery systems for administration of parenteral and oral live vaccines are also discussed.
    关键词: Pharmacology & Pharmacy
    日期: 1999
    關聯: Critical Reviews in Therapeutic Drug Carrier Systems. 1999;16(1):1-83.
    Link to: http://www.begellhouse.com/journals/3667c4ae6e8fd136,2a35f4ea1d04d86e,266c4bc0094b13e3.html
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0743-4863&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000079163700001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032963287
    显示于类别:[徐祖安] 期刊論文

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