國家衛生研究院 NHRI:Item 3990099045/11708
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 924767      線上人數 : 964
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11708


    題名: Candida albicans infection creates a microenvironment favoring MDSC and Th17 and promotes mouse oral cancer incidence
    作者: Liu, KJ;Yang, WC;Chu, PY
    貢獻者: National Institute of Cancer Research
    摘要: Microorganism infection has been reported to associate with many cancers. We adopt a carcinogen-induced mouse oral cancer model to investigate the effect of oral Candida albicans infection on the development of oral cancer. We observed that exposure of Candida increased the incidence of oral cancer. The expression of genes involved in the Th17 development pathway was elevated in the tumor microenvironment. A co-localization of Candida mycelium and presence of IL-1beta, IL-6, IL-17A, IL-17F, and IL-22 was demonstrated. Exposure of mouse oral epithelial cells to curdlan, a component of Candida cell wall, triggered the release of MCP-1 which can recruit monocyte and macrophage. Exposure of mouse monocyte to curdlan in turn modulated the differentiation of macrophages and dendritic cells and promoted the production of arginase, iNOS, IL-1beta, IL-6 ad IL-23. In addition, curdlan promoted the differentiation of myeloid-derived suppressor cells. These conditions may further promote the development of Th17 cells. We demonstrated that Candida albicans infection creates a microenvironment favoring MDSC and Th17 development and promotes mouse oral cancer incidence.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):884.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773604159
    顯示於類別:[劉柯俊] 會議論文/會議摘要

    文件中的檔案:

    檔案 大小格式瀏覽次數
    ISI000453773604159.pdf36KbAdobe PDF265檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋