國家衛生研究院 NHRI:Item 3990099045/11711
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 906651      在线人数 : 936
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11711


    题名: ACTL6a promotes metastasis and predicts poor prognosis of prostate cancer via regulation of YAP and cancer stemness
    作者: Chuu, CP;Lin, CY;Huang, SH;Liao, WY;Tsai, KK
    贡献者: National Institute of Cancer Research;Institute of Cellular and Systems Medicine
    摘要: Using Micro-Western Array (MWA), a high-throughput Western blotting platform, and 434 antibodies targeting epigenetic regulation, we identified expression of 144 proteins significantly changes during the acini morphogenesis (a differentiation procedure) of prostate epithelial cells in 3D culture. ACTL6a, encoding an SWI/SNF subunit linked to stem cell and progenitor cell function, decreases most during the prostate cell differentiation, suggesting that it may be a novel oncogene in PCa. Tissue array reveals that PCa patients with high ACTL6a expression have worse survival rate. Knockdown of ACTL6a suppresses migration and invasion of PCa cells as determined by transwell assay, inhibits metastasis of prostate tumors in orthotopic model in nude mice, as well as reduces ALDH+ PCa cancer stem cells population. MWA analysis indicates that knockdown of ACTL6a reduces YAP and proteins in Hippo pathway, CD44, Sox2, Nanog, KLF4, HDAC1, HDAC3, and MMPs. Overexpression of YAP rescues the suppressive effect of ACTL6a on cancer metastasis. Our finding suggests that ACTL6a promotes metastasis and predicts poor prognosis of prostate cancer via regulation of YAP-Hippo pathway and cancer stemness.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):244.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601079
    显示于类别:[蔡坤志] 會議論文/會議摘要
    [褚志斌] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000453773601079.pdf32KbAdobe PDF282检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈