國家衛生研究院 NHRI:Item 3990099045/11718
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 916899      在线人数 : 1534
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11718


    题名: Determinants of white matter hyperintensity in a community-based population study: The role of high blood pressure and low carotid flow
    作者: Cheng, HM;Chuang, S;Hwang, A;Chen, L;Chen, C;Wang, P
    贡献者: Institute of Population Health Sciences
    摘要: Objective:High blood pressure and low carotid flow are positively associated with acute cerebrovascular disease risk, such as stroke. However, the determinants of white matter hyper-intensity (WMHI) and its association with blood pressure and carotid flow remains unclear. The present study was conducted to investigate the determinants of WMHI in a general population and its associations with carotid flow and blood pressure.Design and method:A total 991 adults (>=50 yrs) from a community-based study, the I-Lan Longitudinal Aging Study, were evaluated for this study. Flow velocities at common and internal carotid artery (CCA and ICA), including peak systolic velocity (PSV) and end diastolic velocity (EDV), were measured by Doppler ultrasound. Systolic and diastolic blood pressure (SBP and DBP) were measured by an automatic oscillometric device. WMHI was measured by brain magnetic resonance imaging. General linear regression was used to evaluate the association between carotid flow, blood pressure, and WMHI.Results:The mean and median of WMHI were 2.20 and 0.857 cm3. SBP (r = 0.30), DBP (r = 0.21), CCA PSV (r = −0.21) and EDV (r = −0.38), and ICA PSV (r = −0.21) and EDV (−0.32) were significantly associated with log-WMHI (all p-values < 0.0001). In the multivariable linear regression model, age, SBP, CCA EDV, fasting blood sugar, and homocystein were independent predictors of WMHI. The WMHI in adults with SBP < 120, 120–129, 130–139, 140–159, and >  = 160 were 1.30, 2.07, 2.28, 3.18 and 4.04 (cm3), respectively (p-value for trend < 0.001), and in adults with EDV < 16, 16–21 and >  = 22 (cm/sec) were 4.58, 2.05, 0.98 (cm3), respectively (p-value for trend < 0.01). The positive association of systolic BP and negative association of EDV with WMHI remained significant in the model with controlling for age, gender, glucose, lipids, inflammatory status, drinking and smoking. The adults with SBP >  = 160 mmHg plus EDV < 16 cm/sec had higher WMH volume (adjusted mean = 3.21 cm3, p-value < 0.001), compared to those with SBP < 120 plus EDV >  = 22 cm/sec.Conclusions:High SBP and low CCA EDV were independently associated w
    日期: 2018-06
    關聯: Journal of Hypertension. 2018 Jun;36(Suppl. 1):E227.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000539638.27187.99
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000455593900686
    显示于类别:[莊紹源] 會議論文/會議摘要

    文件中的档案:

    没有与此文件相关的档案.



    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈