國家衛生研究院 NHRI:Item 3990099045/11722
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    题名: Molecular design of near-infrared fluorescent Pdots for tumor targeting: Aggregation-induced emission: Versus anti-aggregation-caused quenching
    作者: Tsai, WK;Wang, CI;Liao, CH;Yao, CN;Kuo, TJ;Liu, MH;Hsu, CP;Lin, SY;Wu, CY;Pyle, JR;Chen, J;Chan, YH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Semiconducting polymer dots (Pdots) have recently emerged as a new type of ultrabright fluorescent probe that has been proved to be very useful for biomedical imaging. However, Pdots often suffer from serious fluorescence aggregation-caused quenching (ACQ) especially for near-infrared (NIR) fluorescent Pdots. This article compared two strategies to overcome the ACQ effect in near-infrared emissive Pdot systems: aggregation-induced emission (AIE) and anti-aggregation-caused quenching (anti-ACQ). The results show that the anti-ACQ platform outperforms the AIE system. The fluorescence quantum yield of anti-ACQ-based Pdots can be over 50% and the average per-particle brightness of the Pdots is about 5 times higher than that of the commercially available quantum dots. To help understand why the monomer conformations could greatly affect the optical properties of Pdots, molecular dynamics simulations were performed for the first time in such complicated Pdot systems. To demonstrate applications for in vivo fluorescence imaging, both microangiography imaging on living zebrafish embryos and specific tumor targeting on mice were performed. We anticipate that these studies will pave the way for the design of new highly fluorescent Pdot systems.
    日期: 2019-01
    關聯: Chemical science. 2019 Jan;10:198-207.
    Link to: http://dx.doi.org/10.1039/c8sc03510e
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-6520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000454835000018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85059174496
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