Background: Prostate cancer (PCa) is the 5th most common cancer overall in the world. Epigenetic alterations is involved in the development or progression of cancer via regulation of histone modifications. Histone lysine demethylases KDM4C is androgen receptor (AR) co-regulator and modulate AR-mediated transcription. Expression of KDM4C was reported to be higher in castration-resistant prostate cancer (CRPC). Methods: Role of KDM4C in cell proliferation and docetaxel-resistance was determined using MTT assay and 96-well proliferation assay. Effects of KDM4C on PCa migration and invasion was determined by trasnwell assay. Role of KDM4C on cancer stemness was examined using cell sorter. Inhibitory role...
Date:
2018-10
Relation:
Annals of Oncology. 2018 Oct;29(Suppl. 7):Meeting Abstract O1-19-2.
