國家衛生研究院 NHRI:Item 3990099045/11789
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    题名: Immunopathogenic mechanisms and novel immune-modulated therapies in rheumatoid arthritis
    作者: Chen, SJ;Lin, GJ;Chen, JW;Wang, KC;Tien, CH;Hu, CF;Chang, CN;Hsu, WF;Fan, HC;Sytwu, HK
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and anticitrullinated peptide antibodies. The orchestra of the inflammatory process among various immune cells, cytokines, chemokines, proteases, matrix metalloproteinases (MMPs), and reactive oxidative stress play critical immunopathologic roles in the inflammatory cascade of the joint environment, leading to clinical impairment and RA. With the growing understanding of the immunopathogenic mechanisms, increasingly novel marked and potential biologic agents have merged for the treatment of RA in recent years. In this review, we focus on the current understanding of pathogenic mechanisms, highlight novel biologic disease-modifying antirheumatic drugs (DMRADs), targeted synthetic DMRADs, and immune-modulating agents, and identify the applicable immune-mediated therapeutic strategies of the near future. In conclusion, new therapeutic approaches are emerging through a better understanding of the immunopathophysiology of RA, which is improving disease outcomes better than ever.
    日期: 2019-03-16
    關聯: International Journal of Molecular Sciences. 2019 Mar 16;20(6):Article number 1332.
    Link to: http://dx.doi.org/10.3390/ijms20061332
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000464319100004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85063291087
    显示于类别:[司徒惠康] 期刊論文

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