國家衛生研究院 NHRI:Item 3990099045/11831

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11831

Title:	Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol
Authors:	Su, CY;Chen, CC;Chen, HY;Lin, CP;Lin, FH;Fang, HW
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
Date:	2019-06
Relation:	Journal of Dental Sciences. 2019 Jun;14(2):192-197.
Link to:	http://dx.doi.org/10.1016/j.jds.2019.01.002
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1991-7902&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000470085800013
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85063114556
Appears in Collections:	[Feng-Huei Lin] Periodical Articles

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