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http://ir.nhri.org.tw/handle/3990099045/11862
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| Title: | Neonatal hyperbilirubinaemia is associated with a subsequent increased risk of childhood-onset type 1 diabetes |
| Authors: | Liao, PF;Tsai, JD;Chen, HJ;Pan, HH;Hung, TW;Chang, HY;Sheu, JN |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background: Type 1 diabetes (T1D) is one of the most common chronic diseases of childhood. Whether neonatal hyperbilirubinaemia increases the risk of T1D remains unclear. Aim: To estimate the association between neonatal hyperbilirubinaemia and phototherapy and the risk of T1D using a large nationwide population-based cohort. Methods: This retrospective study was conducted using data from the National Health Insurance Research Database in Taiwan from 2001 until 2005. Altogether, 23,784 neonates aged <30 days diagnosed with hyperbilirubinaemia and 47,568 neonates without hyperbilirubinaemia were enrolled and frequency-matched to the hyperbilirubinaemia group by gender, age, parental occupation and urbanisation. Cox regression analysis was performed to estimate hazard ratios (HRs) and 95% confidence intervals (CI). Results: Of the 71,352 neonates included, those with hyperbilirubinaemia had a higher incidence of T1D (4.76 vs 2.68 per 10,000 person-years, p < 0.001) and an earlier mean age at onset of T1D [4.13 (2.80) vs 5.80 (2.67) years, p < 0.001] than those without hyperbilirubinaemia. After adjusting for confounding factors in multivariable analysis, the neonates with hyperbilirubinaemia had a 66% increased risk of developing T1D (HR 1.66, 95% CI 1.26–2.18). Girls had a 1.41-fold (HR 1.41, 95% CI 1.10–1.82) greater risk of T1D than boys. Additionally, neonates with a history of perinatal complications (HR 1.66, 95% CI 0.99–2.80) and neonatal infections (HR 2.13, 95% CI 1.45–3.15) had an increased subsequent risk of T1D. Conclusions: The results suggest that neonatal hyperbilirubinaemia is associated with a subsequently increased risk of childhood-onset T1D. Abbreviations: T1D, type 1 diabetes; CI, confidence interval; NHI, national health insurance; NHIA, National Health Insurance Administration; NHIRD, National Health Insurance Research Database; ICD-9-CM, International Classification of Diseases, Ninth Revision, Clinical Modification; G6PD, glucose-6-phosphate dehydrogenase; LBW, low birthweight; HRs, hazard ratios. |
| Date: | 2020-01-02 |
| Relation: | Paediatrics and International Child Health. 2020 Jan 2;40(1):35-43. |
| Link to: | http://dx.doi.org/10.1080/20469047.2019.1600854 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2046-9047&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000465805400001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85064009761 |
| Appears in Collections: | [張新儀] 期刊論文
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| SCP85064009761.pdf | | 1048Kb | Adobe PDF | 298 | View/Open |
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