tion. A total of 10,295 individuals were initially included, and 9,862 participants were retained after quality control, which consisted of 1,218 (12%) depression individuals based on prior diagnosis of major depressive disorder or high scores of self-report patient health questionnaire for depression and anxiety (scores greater than 3). Genetic association analyses were performed using logistic regression models while adjusted for age and sex. A p-value less than 10-5 was considered with suggestive association signals. Results: Within depressed group, the top three associated SNPs were rs4775785 (P-value=1.20 10-7), rs10162880 (P=4.38 10-7) and rs7177833 (P=5.17 10-7). After gene mapping, these top SNPs were all map to the SHC4 gene, a protein coding gene on chromosome 15. In the nondepressed group, a different set of associated SNPs were observed, with rs11238817 (P=2.16 10-6) and rs11637781 (P=4.41 10-6) showing suggestive signals without mapped to known coding genes. Discussion: There is no overlapping markers or genes for peptic ulcer between the depressed and non-depressed groups, indicating different genetic profiles among the two groups. A replication study is needed with larger sample size, especially for the identified gene located on chromosome 15 in depressed individuals.
Date:
2019-01
Relation:
European Neuropsychopharmacology. 2019 Jan;29(Suppl. 3):S905-S906.
