國家衛生研究院 NHRI:Item 3990099045/11921
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11921


    Title: Trends and factors in antipsychotic use of outpatients with anxiety disorders in Taiwan, 2005-2013: A population-based study
    Authors: Huang, CW;Chiu, YW;Chen, PJ;Yu, NW;Tsai, HJ;Chang, CM
    Contributors: Institute of Population Health Sciences
    Abstract: AIM: Antipsychotics off-label use is common in clinical practice but information is limited to reveal the trends of antipsychotic use in specific mental disorder in Taiwan. This study aimed to examine the trends and associated factors of antipsychotic use among outpatients with anxiety disorders in Taiwan during 2005-2013. METHODS: We assessed the annual prescriptions of antipsychotic use in 9 consecutive years (2005-2013) using the National Health Insurance Research Database among adults (aged >/=18 years) with anxiety disorders in outpatient visits in Taiwan. We applied logistic regression to examine the trends and associated factors of antipsychotic use. RESULTS: The proportion of antipsychotic medication use for anxiety disorder increased from 8.4% in 2005 to 9.1% in 2013. First-generation antipsychotics (FGAs) use is more than that of second-generation antipsychotics (SGAs) in patients with anxiety disorder through the 9-year period. Sulpiride and flupentixol were the two-most common FGAs in the treatment of anxiety disorder. Patients with specific anxiety disorder (traumatic stress disorder, panic disorder/agoraphobia, generalized anxiety disorder, and obsessive compulsive disorder), female gender, younger adult (age <65 years), comorbidity with major depression or minor depression, antidepressants concurrent use and visits to psychiatrists, medical centers and primary care were significantly tended to prescribe antipsychotics. CONCLUSION: Antipsychotic off-label use significantly increased among patients with anxiety disorder in this national representative cohort. Such increased use of antipsychotics could be driven by augmentation of their prescription for major depression. As their efficacy and safety remain uncertain, further study is warranted.
    Date: 2019-08
    Relation: Psychiatry and Clinical Neurosciences. 2019 Aug;73(8):501-507.
    Link to: http://dx.doi.org/10.1111/pcn.12861
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1323-1316&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000478903200010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067349063
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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