國家衛生研究院 NHRI:Item 3990099045/11922
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    題名: The effect of antidementia drugs on mortality in patients with Alzheimer's disease
    作者: Lin, WH;Lin, CH;Hou, PH;Lan, TH
    貢獻者: Center for Neuropsychiatric Research
    摘要: INTRODUCTION: Alzheimer's disease is associated with a higher mortality rate after the diagnosis. We hypothesized that patients with Alzheimer's disease who received antidementia drugs may have a lower mortality rate than those without such treatment. METHODS: Patients with newly diagnosed Alzheimer's disease aged 65 years during 2001-2006 were identified in the National Health Institute Research Database, Taiwan. We included patients with Alzheimer's disease who received antidementia drugs as the exposure group (ADD group), and compared them with a non-exposure group who did not receive any antidementia drugs (non-ADD group) matched for age at the index date, gender and Charlson Comorbidity Index score before the index date. All-cause mortality rates and Charlson Comorbidity Index scores at one and two years after the index date were compared between the ADD and non-ADD groups. RESULTS: There were 529 patients in non-ADD group and 529 in the ADD group. The mortality rate was significantly lower in the ADD group compared with the non-ADD group (42% versus 58.6%; p<0.0001). CONCLUSION: Our results suggest that antidementia drugs may have a protective effect against mortality in patients with Alzheimer's disease.
    日期: 2019-08
    關聯: Journal of Psychopharmacology. 2019 Aug;33(8):986-993.
    Link to: http://dx.doi.org/10.1177/0269881119845795
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0269-8811&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000475351000006
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85066825852
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