國家衛生研究院 NHRI:Item 3990099045/11998
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    題名: Development, integration and use of an ultra-high-strength gradient system on a human-size 3 T magnet for small animal MRI
    作者: Cho, KH;Huang, SM;Choi, CH;Chen, MJ;Chiang, HH;Buschbeck, RP;Farrher, E;Shah, NJ;Garipov, R;Chang, CP;Chang, H;Kuo, LW
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: This study aims to integrate an ultra-high-strength gradient coil system on a clinical 3 T magnet and demonstrate its preclinical imaging capabilities. Dedicated phantoms were used to qualitatively and quantitatively assess the performance of the gradient system. Advanced MR imaging sequences, including diffusion tensor imaging (DTI) and quantitative susceptibility mapping (QSM), were implemented and executed on an ex vivo specimen as well as in vivo rats. The DTI and QSM results on the phantom agreed well with those in the literature. Furthermore, studies on ex vivo specimens have demonstrated the applicability of DTI and QSM on our system to probe microstructural changes in a mild traumatic brain injury rat model. The feasibility of in vivo rat DTI was also demonstrated. We showed that the inserted ultra-high-strength gradient coil was successfully integrated on a clinically used magnet. After careful tuning and calibration, we verified the accuracy and quantitative preclinical imaging capability of the integrated system in phantom and in vivo rat brain experiments. This study can be essential to establish dedicated animal MRI platform on clinical MRI scanners and facilitate translational studies at clinical settings.
    日期: 2019-06-03
    關聯: PLoS ONE. 2019 Jun 3;14(6):Article number e0217916.
    Link to: http://dx.doi.org/10.1371/journal.pone.0217916
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000469915700034
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85066637083
    顯示於類別:[郭立威] 期刊論文
    [張恕(2004-2017)] 期刊論文

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