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    日期题名關聯
    2024-06 UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis Journal of Autoimmunity. 2024 Jun;146:Article number 103221.
    2024-03-27 Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck Journal of Biomedical Science. 2024 Mar 27;31:Article number 33.
    2024-01-15 The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling Nature Communications. 2024 Jan 15;15:Article number 532.
    2023-12-05 Dual-specificity phosphatase 6 deficiency attenuates arterial-injury-induced intimal hyperplasia in mice International Journal of Molecular Sciences. 2023 Dec 05;24(24):Article number 17136.
    2023-11-01 DUSP8 induces TGF-beta–stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-Alpha Journal of Clinical Investigation. 2023 Nov 01;133(21):Article number e166269.
    2023-08-22 ACE2 in chronic disease and COVID-19: Gene regulation and post-translational modification Journal of Biomedical Science. 2023 Aug 22;30:Article number 71.
    2023-04-22 DUSP6 deficiency attenuates neurodegeneration after global cerebral ischemia International Journal of Molecular Sciences. 2023 Apr 22;24(9):Article number 7690.
    2023-02-10 Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis BMC Medicine. 2023 Feb 10;21:Article number 46.
    2022-07-27 SARS-CoV-2 spike protein enhances MAP4K3/GLK-induced ACE2 stability in COVID-19 EMBO Molecular Medicine. 2022 Jul 27:Article number e15904.
    2022-07-18 MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKK beta and inducing IKK beta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics. 2022 Jul 18;12(12):5744-5760.
    2022-02-18 Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice iScience. 2022 Feb 18;25(2):Article number 103738.
    2022-02 Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus Annals of the Rheumatic Diseases. 2022 Feb;81(2):243-254.
    2022-01 Induction of interferon-gamma and tissue inflammation by overexpression of eosinophil cationic protein in T cells and exosomes Arthritis and Rheumatology. 2022 Jan;74(1):92-104.
    2021-10-25 BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus Theranostics. 2021 Oct 25;11(20):9953-9966.
    2020-10-12 Structural insights into the active site formation of dusp22 in n-loop-containing protein tyrosine phosphatases International Journal of Molecular Sciences. 2020 Oct 12;21(20):Article number 7515.
    2020-08-12 DUSP11 attenuates lipopolysaccharide-induced macrophage activation by targeting TAK1 Journal of Immunology. 2020 Aug 12;205(6):1644-1652.
    2019-11-13 MAP4K family kinases and DUSP family phosphatases in T-Cell signaling and systemic lupus erythematosus Cells. 2019 Nov 13;8(11):Article number 1433.
    2019-10-22 MAP4K3/GLK in autoimmune disease, cancer and aging Journal of Biomedical Science. 2019 Oct 22;26:Article number 82.
    2019-10 AhR-ROR-gammat complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus FASEB Journal. 2019 Oct;3(10):11469-11480.
    2019-10 MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1 Cancer Research. 2019 Oct;79(19):4978-4993.
    2019-05-30 Regulation of Dual-Specificity Phosphatase (DUSP) ubiquitination and protein stability International Journal of Molecular Sciences. 2019 May 30;20(11):Article number 2668.
    2018-12 RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell Biochimica et Biophysica Acta-Molecular Cell Research. 2018 Feb;1865(2):259-272.
    2018-12 Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation FASEB Journal. 2018 Dec;32(12):6760-6770.
    2018-09-12 GLK-IKKbeta signaling induces dimerization and translocation of the AhR-RORgammat complex in IL-17A induction and autoimmune disease Science Advances. 2018 Sep 12;4(9):Article number eaat5401.
    2018-09-06 RBM4A-SRSF3-MAP4K4 splicing cascade constitutes a molecular mechanism for regulating brown adipogenesis International Journal of Molecular Sciences. 2018 Sep 6;19(9):Article number 2646.
    2017-11 Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration Oncogene. 2017 Nov;36(47):6509-6517.
    2017-01-07 MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes Journal of Biomedical Science. 2017 Jan 7;24:Article number 4.
    2016-08 Downregulation of the phosphatase JKAP/DUSP22 in T Cells as a potential new biomarker of systemic lupus erythematosus nephritis Oncotarget. 2016 Aug;7(36):57593-57605.
    2016-07 GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer Oncotarget. 2016 Jul;7(27):41748-41757.
    2016-07 Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase Oncotarget. 2016 Jul;7(31):49765-49776.
    2016-03-08 Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients Oncotarget. 2016 Mar 8;7(10):10976-10989.
    2016-01 MAP4K family kinases in immunity and inflammation Advances in Immunology. 2016 Jan;129:277-314.
    2014-08-06 HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance Nature Communications. 2014 Aug 6;5:Article number 4602.
    2014-04-09 The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck Nature Communications. 2014 Apr 9;5:Article number 3618.
    2014-02-15 Dual-specificity Phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation Journal of Immunology. 2014 Feb 15;192(4):1547-1557.
    2013-10 Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis Arthritis and Rheumatism. 2013 Oct;65(10):2573-2582.
    2012-08-06 Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker BMC Medicine. 2012 Aug 6;10(1):Article number 84.
    2012-07 Regulation of PKC-theta function by phosphorylation in T cell receptor signaling Frontiers in Immunology. 2012 Jul;3:Article number 197.
    2011-10 The kinase GLK controls autoimmunity and NF-kappa B signaling by activating the kinase PKC-theta in T cells Nature Immunology. 2011 Oct;12(11):1113-1118.
    2009-06 Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis Hepatology. 2009 Jun;49(6):1962-1971.
    2008-11 Up-regulation of activating transcription factor-5 suppresses SAP expression to activate T cells in hemophagocytic syndrome associated with Epstein-Barr virus infection and immune disorders American Journal of Pathology. 2008 Nov;173(5):1397-1405.
    2007-09 Pathogenesis and mechanism of disease progression from hemophagocytic lymphohistiocytosis to Epstein-Barr virus-associated T-cell lymphoma: Nuclear factor-kappa B pathway as a potential therapeutic target Cancer Science. 2007 Sep;98(9):1281-1287.
    2007-05 Epstein-Barr virus (EBV) latent membrane protein-1 down-regulates tumor necrosis factor-alpha (TNF-alpha) receptor-1 and confers resistance to TNF-alpha-induced apoptosis in T cells - Implication for the progression to T-cell lymphoma in EBV-associated hemophagocytic syndrome American Journal of Pathology. 2007 May;170(5):1607-1617.
    2005-11-01 Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome Blood. 2005 Nov;106(9):3090-3096.

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