國家衛生研究院 NHRI:Item 3990099045/12030
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    题名: Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma
    作者: Chen, M;Yang, MH;Chang, MM;Tyan, YC;Chen, YMA
    贡献者: National Mosquito-Borne Diseases Control Research Center
    摘要: Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo[a]pyrene, aflatoxin B1, and aristocholic acid. There is also increasing evidence suggesting a role of GNMT deficiency in liver carcinogenesis. In this review, we discuss the role of GNMT in the detoxification of xenobiotics and the mechanism of GNMT suppression during liver tumorigenesis. The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. We describe the potential use of GNMT in gene therapy and we introduce the development of a GNMT promoter reporter assay that can be used to screen medicinal drugs and herbal libraries for natural compounds with anti-cancer properties.
    日期: 2019-09-01
    關聯: Toxicology and Applied Pharmacology. 2019 Sep 1;378:Article number 114607.
    Link to: http://dx.doi.org/10.1016/j.taap.2019.114607
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0041-008X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000477917100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067862481
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