國家衛生研究院 NHRI:Item 3990099045/12035
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12035


    Title: Development of a modified surgical technique for simulating ischemic cerebral cortex injury in rats
    Authors: Yeh, CF;Chuang, TY;Hung, YW;Lan, MY;Tsai, CH;Huang, HX;Lin, YY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Background/Aim: Middle cerebral artery occlusion (MCAO) in rodents is an essential animal model for research focusing on ischemic stroke. To date, several kinds of surgical methods for MCAO have been developed and the craniotomy method has the advantage of direct visualization of the middle cerebral artery (MCA). MCAO at a more proximal site produces better surgical results, but it is a more invasive technique. The aim of this study was to evolve the surgical technique for simulating ischemic cerebral cortex injury in rats. Materials and Methods: To approach proximal MCA with a less invasive procedure, a modified surgical technique for MCAO in rats was developed. Besides, rats receiving the modified and conventional method were compared with regard to infarct volume and by behavioral tests. Results: Following craniotomy, we proposed that the inferior edge of the craniotomy should be enlarged with fine forceps. This modified surgical method induces larger infarct volume, significant behavioral impairment and can induce ischemic stroke. Additionally, it does not significantly increase the operation time, and has produced no obvious complications. Conclusion: This modified surgical technique may serve as a practical method for performing MCAO.
    Date: 2019-07
    Relation: In Vivo. 2019 Jul-Aug;33(4):1175-1181.
    Link to: http://dx.doi.org/10.21873/invivo.11588
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0258-851X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000474906500021
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069292146
    Appears in Collections:[Others] Periodical Articles

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