國家衛生研究院 NHRI:Item 3990099045/12085
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 858793      線上人數 : 788
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12085


    題名: Efficacy of frontline antibiotics therapy in the treatment of Helicobacter pylori-negative gastric low-grade mucosa-associated lymphoid tissue lymphoma
    作者: Kuo, SH;Yeh, KH;Wu, MS;Lin, CW;Tsai, HJ;Wei, MF;Lee, HW;Liou, JM;Chen, LT;Cheng, AL
    貢獻者: National Institute of Cancer Research
    摘要: Background: Previous series reports revealed that certain proportions of Helicobacter pylori (HP)-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma may respond to antibiotics treatment. In this explorative study, we assess the response rate, the long-term disease-free, and potential biomarkers of localized HP-negative gastric MALT lymphoma patients receiving frontline antibiotics. Methods: Between 2007 and 2014, a total of 23 stage IE/IIE1 HP-negative gastric low-grade MALT lymphoma patients who received frontline HP eradication (HPE) regimen, consisting of amoxicillin, clarithromycin, and a proton-pump inhibitor, were included in this study. HP-negative status was defined by negative results for the biopsy urease test, histology, C13-Urea breath test and serology. The presence or absence of t(11;18)(q21;q21) was determined using multiplex RT-PCR to amplify the API2-MALT1 transcript. The expression of BCL10 and NF-κB was assessed using immunohistochemistry. Tumors that had resolved to complete remission (CR) score of GELA histological grading system after antibiotics were considered antibiotics-responsive. Results: Tumors were of stage I in twenty and IIE-1 in three. We observed CR in 7 (30.4%) of 23 patients, and the median time to CR was 6 months (95% CI, 3.43–8.57 mo). At a median follow-up of 26.9 months, all patients with CR after HPE therapy were alive and free of lymphomas. The API2-MALT1 fusion transcript was detected in 7 (43.7%) of 16 antibiotics-unresponsive cases (P = 0.057), but in none of 7 antibiotics-responsive cases. BCL10 nuclear expression was significantly higher in antibiotics-unresponsive than antibiotics-responsive tumors (12 of 16 [75.0%] vs 1 of 7 [14.3%]; P = 0.019). Nuclear expression of NF-κB was also significantly associated with antibiotics unresponsiveness of tumors (P = 0.027). Conclusions: A pertinent portion of HP-negative gastric MALT lymphoma patients are still responsive to frontline HPE. In addition to t(11;18)(q21;q21), nuclear expression of BCL10 or NF-κB is predictive of antibiotics-unresponsive status of HP-negative gastric MALT lymphoma.
    日期: 2016-05
    關聯: Journal of Clinical Oncology. 2016 May;34(15, Suppl. S):Abstract number e19024.
    Link to: http://dx.doi.org/10.1200/JCO.2016.34.15_suppl.e19024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000404711505117
    顯示於類別:[蔡慧珍] 期刊論文
    [陳立宗] 期刊論文

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋