國家衛生研究院 NHRI:Item 3990099045/12088

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chia-Wen Wu > Periodical Articles > Item 3990099045/12088

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12088

Title:	Biocompatible and multifunctional gold nanorods for effective photothermal therapy of oral squamous cell carcinoma
Authors:	Liao, YT;Liu, CH;Chin, Y;Chen, SY;Liu, SH;Hsu, YC;Wu, KCW
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Herein, a cysteine-functionalized alginate was used to replace cytotoxic cetyltrimethylammonium bromide (CTAB) on gold nanorods (GNRs) by gold-thiol bonding. The characterization shows that the alginate-modified GNRs (GNR@Alg-Cys) were 137 nm in length (measured by zetasizer) with a negative surface charge (-28.4 mV). The GNR@Alg-Cys showed an intense absorption at 800 nm, indicating the potential of GNR@Alg-Cys for NIR-excited photothermal therapy (PTT). To target cancer cells, a cyclic peptide, c(RGDfK)KKK, was further modified on GNR@Alg-Cys (denoted as GNR@Alg-Cys/RGD). In vitro experiments reveal the apparently enhanced cell viability under a high dose of GNRs as well as the death of SAS-3 cell lines exposed to a single-wavelength laser (808 nm). The animal study revealed that the volume of GNR@Alg-Cys/RGD-treated laser-exposed tumor was reduced five times when compared with that in the case of the control group (PBS-treated tumor). Furthermore, the in vivo toxicity of GNR@Alg-Cys/RGD was evaluated, and no significant effect was observed on the functions of liver and kidneys after PTT.
Date:	2019-07
Relation:	Journal of Materials Chemistry B. 2019 Jul;7(28):4451-4460.
Link to:	http://dx.doi.org/10.1039/c9tb00574a
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000475804400007
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069178006
Appears in Collections:	[Chia-Wen Wu] Periodical Articles

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