國家衛生研究院 NHRI:Item 3990099045/12103
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12103


    Title: Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women
    Authors: Wong, JYY;Zhang, H;Hsiung, CA;Shiraishi, K;Yu, K;Matsuo, K;Wong, MP;Hong, YC;Wang, J;Seow, WJ;Wang, Z;Song, M;Kim, HN;Chang, IS;Chatterjee, N;Hu, W;Wu, C;Mitsudomi, T;Zheng, W;Kim, JH;Seow, A;Caporaso, NE;Shin, MH;Chung, LP;An, SJ;Wang, P;Yang, Y;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YT;Cai, Q;Yin, Z;Kim, YC;Bassig, BA;Chang, J;Ho, JCM;Ji, BT;Daigo, Y;Ito, H;Momozawa, Y;Ashikawa, K;Kamatani, Y;Honda, T;Hosgood, HD;Sakamoto, H;Kunitoh, H;Tsuta, K;Watanabe, SI;Kubo, M;Miyagi, Y;Nakayama, H;Matsumoto, S;Tsuboi, M;Goto, K;Shi, J;Song, L;Hua, X;Takahashi, A;Goto, A;Minamiya, Y;Shimizu, K;Tanaka, K;Wei, F;Matsuda, F;Su, J;Kim, YH;Oh, IJ;Song, F;Su, WC;Chen, YM;Chang, GC;Chen, KY;Huang, MS;Chien, LH;Xiang, YB;Park, JY;Kweon, SS;Chen, CJ;Lee, KM;Blechter, B;Li, H;Gao, YT;Qian, B;Lu, D;Liu, J;Jeon, HS;Hsiao, CF;Sung, JS;Tsai, YH;Jung, YJ;Guo, H;Hu, Z;Wang, WC;Chung, CC;Burdett, L;Yeager, M;Hutchinson, A;Berndt, SI;Wu, W, .;et al.
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research
    Abstract: We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p=0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR=1.31, 95% CI: 1.03, 1.66, p=0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women.
    Date: 2020-03
    Relation: Genomics. 2020 Mar;112(2):1223-1232.
    Link to: http://dx.doi.org/10.1016/j.ygeno.2019.07.008
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0888-7543&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000514071600020
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85068966697
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles
    [I-Shou Chang] Periodical Articles
    [Shih-Sheng Jiang] Periodical Articles

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