國家衛生研究院 NHRI:Item 3990099045/12109
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 910652      在线人数 : 864
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12109


    题名: Nicastrin deficiency induces tyrosinase-dependent depigmentation and skin inflammation
    作者: Hsu, CH;Liou, GG;Jiang, YJ
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Skin depigmentation diseases, such as vitiligo, are pigmentation disorders that often destroy melanocytes. However, their pathological mechanisms remain unclear and, therefore, promising treatments or prevention have been lacking. Here we demonstrate that a zebrafish insertional mutant showing a significant reduction of nicastrin transcript possesses melanosome maturation defect, Tyrosinase-dependent mitochondrial swelling and melanophore cell death. The depigmentation phenotypes are proven to be a result of gamma-secretase inactivation. Furthermore, live imaging demonstrates that macrophages are recruited to and can phagocytose melanophore debris. Thus, we characterize a potential zebrafish depigmentation disease model, nicastrin(hi1384) mutants, which can be used for further treatment/drug development of diseases related to skin depigmentation and/or inflammation.
    日期: 2020-02
    關聯: Journal of Investigative Dermatology. 2020 Feb;140(2):404-414.e13.
    Link to: http://dx.doi.org/10.1016/j.jid.2019.07.702
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-202X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000508449700029
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85075398490
    显示于类别:[江運金] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB31437444.pdf39393KbAdobe PDF346检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈