國家衛生研究院 NHRI:Item 3990099045/12121
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    题名: Genotypic and phenotypic characteristics of aeromonas isolates from fish and patients in Tainan city
    作者: Wu, CJ;Ko, WC;Lee, NY;Su, SL;Li, CW;Li, MC;Chen, YW;Su, YC;Shu, CY;Lin, YT;Chen, PL
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: The present study aimed to isolate Aeromonas from fish sold in the markets as well as in sushi and seafood shops and compare their virulence factors and antimicrobial characteristics with those of clinical isolates. Among the 128 fish isolates and 47 clinical isolates, A. caviae, A. dhakensis, and A. veronii were the principal species. A. dhakensis isolates carried at least 5 virulence genes, more than other Aeromonas species. The predominant genotype of virulence genes was hlyA/lip/alt/col/el in both A. dhakensis and A. hydrophila isolates, alt/col/ela in A. caviae isolates, and act in A. veronii isolates. A. dhakensis, A. hydrophila, and A. veronii isolates more often exhibited hemolytic and proteolytic activity and showed greater virulence than A. caviae in Caenorhabditis elegans and the C2C12 cell line. However, the link between the genotypes and phenotypes of the studied virulence genes in Aeromonas species is not evident. Among the four major clinical Aeromonas species, nearly all (99.0%) A. dhakensis, A. hydrophila, and A. veronii isolates harbored bla CphA, which encodes a carbapenemase, but only a minority (6.7%, 7/104) were nonsusceptible to carbapenem. Regarding AmpC beta-lactamase genes, bla AQU-1 was exclusively found in A. dhakensis isolates and bla MOX3 only in A. caviae isolates, but only 7.6% (6) of the 79 Aeromonas isolates carrying bla AQU-1 or bla MOX3 exhibited a cefotaxime resistance phenotype. In conclusion, fish Aeromonas isolates carry a variety of combinations of virulence and ss-lactamase resistance genes and exhibit virulence phenotypes and antimicrobial resistance profiles similar to those of clinical isolates.IMPORTANCE Aeromonas species can cause severe infections in immunocompromised individuals upon exposure to virulent pathogens in the environment, but the characteristics of environmental Aeromonas species remain unclear. Our study showed several pathogenic Aeromonas species possessing virulence traits and antimicrobial resistance similar to those of Aeromonas isolates causing clinical diseases were present in fish intended for human consumption in Tainan City.
    日期: 2019-10
    關聯: Applied and Environmental Microbiology. 2019 Oct;85(21):Article number e01360-19.
    Link to: http://dx.doi.org/10.1128/aem.01360-19
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0099-2240&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000490946700008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85073484080
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