國家衛生研究院 NHRI:Item 3990099045/12162
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    题名: Clonality of fluconazole-nonsusceptible Candida tropicalis in bloodstream infections, Taiwan 2011-2017
    作者: Chen, PY;Chuang, YC;Wu, UI;Sun, HY;Wang, JT;Sheng, WH;Lo, HJ;Wang, HY;Chen, YC;Chang, SC
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Candida tropicalis is the leading cause of non-C. albicans candidemia in tropical Asia and Latin America. We evaluated isolates from 344 patients with an initial episode of C. tropicalis candidemia. We found that 58 (16.9%) patients were infected by fluconazole-nonsusceptible (FNS) C. tropicalis with cross resistance to itraconazole, voriconazole, and posaconazole; 55.2% (32/58) of patients were azole-naive. Multilocus sequence typing analysis revealed FNS isolates were genetically closely related, but we did not see time- or place-clustering. Among the diploid sequence types (DSTs), we noted DST225, which has been reported from fruit in Taiwan and hospitals in Beijing, China, as well as DST376 and DST505-7, which also were reported from hospitals in Shanghai, China. Our findings suggest cross-boundary expansion of FNS C. tropicalis and highlight the importance of active surveillance of clinical isolates to detect dissemination of this pathogen and explore potential sources in the community.
    日期: 2019-09
    關聯: Emerging Infectious Diseases. 2019 Sep;25(9):1668-1675.
    Link to: http://dx.doi.org/10.3201/eid2509.190520
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1080-6040&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000482626000007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85071431887
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