國家衛生研究院 NHRI:Item 3990099045/12167
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 915319      在线人数 : 1286
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12167


    题名: Association between reservoir and cognitive function among elderly population
    作者: Chen, C;Chuang, SY;Cheng, HM;Pan, WH
    贡献者: Institute of Population Health Sciences
    摘要: Objective:Carotid-femoral pulse wave velocity (cf-PWV) has been associated with cognitive function and brain structure. It remains unknown whether other parameters of arterial mechanical function, such as those derived from the reservoir-wave theory, contribute to the development of cognitive dysfunction associated with vascular aging. Thus, the purpose of the present study was to investigate the associations of the reservoir-wave parameters with cognitive function in a community-based sample.Design and method:A total of 822 seniors (aged >=60 years) participated in the sixth wave survey of the Cardiovascular Disease Risk Factors two-Township study and received the Mini-Mental State Examination (MMSE) to evaluate the global cognitive function. cf-PWV was measured using carotid and femoral arterial tonometry. Reservoir-wave analysis was performed on the calibrated ensemble-average carotid pressure waveform to derive peak of reservoir pressure, amplitude of reservoir pressure, excess pressure integral, reservoir pressure integral, systolic and diastolic (DC) rate constants.Results:In univariable analysis, cf-PWV, amplitude of reservoir pressure, peak reservoir pressure, XSPI, and DC were significantly associated with MMSE (all P < 0.05). In multivariable analysis adjusting for age, sex, and education, only cf-PWV (std-B = −0.116, p = 0.0019) and DC (std-B = −0.086, p = 0.015) were significantly associated with MMSE. DC remained significantly associated with MMSE when cf-PWV was also adjusted (std-B = −0.106, P = 0.0048). The proportion of cognitive impairment (MMSE < 26) was 18.79% for high DC and 8.93% for low DC (P < 0.001); and 19.22% for high cf-PWV and 8.33% for low cf-PWV (P < 0.001). Subjects with high DC and high cf-PWV had a 2.95 fold-risk (95% confidence intervals: 1.35–6.35) for cognitive impairment when compared with subjects with low DC and low cf-PWV (P < 0.0001), when age, sex, and education were accounted for.Conclusions:In an elderly population, DC from the reservoir-wave analysis was significantly associated with cognitive function independent of cf-PWV.
    日期: 2019-07
    關聯: Journal of Hypertension. 2019 Jul;37:e276.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000573516.05155.9b
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000481429700817
    显示于类别:[莊紹源] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000481429700817.pdf202KbAdobe PDF262检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈