國家衛生研究院 NHRI:Item 3990099045/12238
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    題名: Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)
    作者: Chang, CP;Chang, SC;Chuang, SC;Berthiller, J;Ferro, G;Matsuo, K;Wunsch-Filho, V;Toporcov, TN;de Carvalho, MB;La Vecchia, C;Olshan, AF;Zevallos, JP;Serraino, D;Muscat, J;Sturgis, EM;Li, G;Morgenstern, H;Levi, F;Dal Maso, L;Smith, E;Kelsey, K;McClean, M;Vaughan, TL;Lazarus, P;Ramroth, H;Chen, C;Schwartz, SM;Winn, DM;Bosetti, C;Edefonti, V;Garavello, W;Negri, E;Hayes, RB;Purdue, MP;Boccia, S;Cadoni, G;Shangina, O;Koifman, R;Curado, MP;Vilensky, M;Swiatkowska, B;Herrero, R;Franceschi, S;Benhamou, S;Fernandez, L;Menezes, AMB;Daudt, AW;Mates, D;Schantz, S;Yu, GP;Lissowska, J;Brenner, H;Fabianova, E;Rudnai, P;Brennan, P;Boffetta, P;Zhang, ZF;Hashibe, M;Lee, YA
    貢獻者: Institute of Population Health Sciences
    摘要: BACKGROUND: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. METHODS: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. RESULTS: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. >/=30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. >/=30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. CONCLUSIONS: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.
    日期: 2019-10-03
    關聯: Cancer Epidemiology. 2019 Oct 3;63:Article number 101615.
    Link to: http://dx.doi.org/10.1016/j.canep.2019.101615
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1877-7821&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000504659600017
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85072785945
    顯示於類別:[莊淑鈞] 期刊論文

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