國家衛生研究院 NHRI:Item 3990099045/12246
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    题名: Enhanced survival of human-induced pluripotent stem cell transplant in parkinsonian rat brain by locally applied cyclosporine
    作者: Sheyner, M;Yu, SJ;Wang, Y
    贡献者: Center for Neuropsychiatric Research
    摘要: A major limitation with cell transplantation in patients is the unimpressive number of cells survived. The death of grafted cells involves apoptosis and immunorejection. In this review, we encapsulate the recent preclinical development that improves the survival of grafted cells and mitigates the immunorejection of human-induced pluripotent stem cells (iPSCs) through co-grating nanoparticles-containing cyclosporine A (NanoCsA) in hemiparkinsonian rats. The study supported the notion that NanoCsA allows for long-lasting CsA discharge and limits immunorejection of human iPSC xenograft in a 6-hydroxydopamine Parkinson's disease rat model.
    日期: 2019-07
    關聯: Brain Circulation. 2019 Jul-Sep;5(3):130-133.
    Link to: http://dx.doi.org/10.4103/bc.bc_40_19
    显示于类别:[王昀] 期刊論文
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