國家衛生研究院 NHRI:Item 3990099045/12251
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    题名: Serum level and activity of butylcholinesterase: A biomarker for post-stroke dementia
    作者: Chen, YC;Chou, WH;Fang, CP;Liu, TH;Tsou, HH;Wang, Y;Liu, YL
    贡献者: Center for Neuropsychiatric Research;Institute of Population Health Sciences
    摘要: Cholinergic neurotransmission regulates the immune response and inhibits cytokine release after stroke. The changes in the level/activity of blood cholinesterase (ChE) in patients with post-stroke dementia (PSD) are less known. This study aimed to examine post-stroke plasma acetylcholinesterase (AChE) and butylcholinesterase (BChE) and determine whether they are biomarkers for PSD. Thirty patients with PSD, 87 post-stroke patients without dementia (PSNoD), and 117 age- and gender-matched healthy controls were recruited. Missense genetic variants AChE rs1799806 and BChE rs1803274 were genotyped. The plasma AChE level did not differ between the PSD and PSNoD groups. However, BChE levels were significantly lower in the PSD than in the PSNoD group (3300.66 +/- 515.35 vs 3855.74 +/- 677.60 ng/mL, respectively; p = 0.0033). The activities of total ChE, BChE, and AChE were all lower in the PSD group (19,563.33 +/- 4366.03, 7650.17 +/- 1912.29, 11,913.17 +/- 2992.42 mU/mL, respectively) than in the PSNoD group (23,579.08 +/- 5251.55, 9077.72 +/- 1727.28, and 14,501.36 +/- 4197.17 mU/mL, respectively). When further adjusting for age and sex, significance remained in BChE level and activity and in total ChE activity. BChE rs1803274 was associated with reduced BChE activity, while AChE rs1799806 did not influence AChE activity. The level and activity of BChE, but not of AChE, were decreased in PSD patients and may therefore aid in PSD diagnosis.
    日期: 2019-10-24
    關聯: Journal of Clinical Medicine. 2019 Oct 24;8(11):Article number 1778.
    Link to: http://dx.doi.org/10.3390/jcm8111778
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2077-0383&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000502294400021
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079541415
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