國家衛生研究院 NHRI:Item 3990099045/1226
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    題名: Tyrosine kinases and gastric cancer
    作者: Lin, WC;Kao, HW;Robinson, D;Kung, HJ;Wu, CW;Chen, HC
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Carcinoma of the stomach is one of the most prevalent cancer types in the world today, Two major forms of gastric cancer are distinguished according to their morphological and clinicopathological classifications (well differentiated/intestinal type and poorly differentiated/diffuse type), characteristics that could also be attributed to the altered expression of different types of oncogenes or tumor suppressor genes. Significant differences exist for gastric cancer incidence comparing people of different ethnic origins, implicating various genetic and epigenetic factors for gastric oncogenesis, There are only a limited number of molecular markers available for gastric cancer detection and prognostic evaluation, among which are tyrosine kinases, There is convincing evidence that tyrosine kinases are involved in oncogenesis and disease progression for many human cancers. Amplifications of certain tyrosine kinases (c-met, k-sam and cr erb2/neu) have been associated with human gastric cancer progression. Alternatively spliced transcripts and enhanced protein-expression levels for some of these tyrosine kinases are correlated,vith clinical outcomes for gastric cancer patients. With advent of high throughput techniques, it is now possible to detect nearly all expressed tyrosine kinases in a single screen. This increases the chance to identify additional tyrosine kinases as predictive markers for gastric cancers. In this article, we will first review the literature data concerning certain tyrosine kinases implicated in gastric carcinogenesis and then summarize more recent work which pro, ide comprehensive tyrosine kinase profiles for gastric cancer specimens and cell lines, Two new gastric cancer molecular markers (tie-1 and mkk4) have been identified through the use of these profiles and demonstrated effective as clinical prognostic indicators.
    關鍵詞: Biochemistry & Molecular Biology;Oncology;Cell Biology;Genetics & Heredity
    日期: 2000-11-20
    關聯: Oncogene. 2000 Nov;19(49):5680-5689.
    Link to: http://dx.doi.org/10.1038/sj.onc.1203924
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000165659300015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034693755
    顯示於類別:[陳華鍵(1997-2001)] 期刊論文

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