國家衛生研究院 NHRI:Item 3990099045/12337
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    题名: Prognostic role of RECK in pathological outcome-dependent buccal mucosa squamous cell carcinoma
    作者: Chen, HC;Tseng, YK;Shu, CW;Fu, TY;Liou, HH;Huang, CH;Chen, CC;Wang, JS;Wu, PC;Ger, LP;Hung, WC;Liu, PF
    贡献者: National Institute of Cancer Research
    摘要: Background: Buccal mucosal squamous cell carcinoma (BMSCC) is an aggressive oral cancer. Moreover, reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a well-known tumor suppressor in many cancers. Our aim was to investigate the association of RECK expression with prognosis in BMSCC patients with different clinicopathological features. Materials and Methods: The expression level of RECK was determined by immunohistochemistry using tissue microarrays containing specimens from 193 BMSCC patients. The association of RECK expression with outcomes in BMSCC patients stratified by different clinicopathological features was analyzed by Cox proportional hazards models. Results: The low expression level of RECK was associated with shorter disease-specific survival, especially in patients with age >40 years, moderate or poor cell differentiation, advanced pathological stage, and history of postoperative radiotherapy. However, the low expression level of RECK was not associated with poor disease-free survival, except in BMSCC patients with age ≦40 years, advanced pathological stage and lymph node metastasis. Furthermore, RECK-knockdowned cells showed higher cell viability and abilities of invasion/migration, indicating that RECK might be a tumor suppressor for tumor progression in oral cancer. Conclusion: The low expression of RECK might be a potential prognostic biomarker for pathological outcome-dependent BMSCC patients.
    日期: 2020-01
    關聯: Oral Diseases. 2020 Jan;26(1):62-71.
    Link to: http://dx.doi.org/10.1111/odi.13214
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1354-523X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000496526700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85075135419
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