國家衛生研究院 NHRI:Item 3990099045/12349
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12349


    Title: A supramolecular trap to increase the antibacterial activity of colistin
    Authors: Liao, FH;Wu, TH;Yao, CN;Kuo, SC;Su, CJ;Jeng, US;Lin, SY
    Contributors: Institute of Biomedical Engineering and Nanomedicine;National Institute of Infectious Diseases and Vaccinology
    Abstract: A strong attractive force between antibiotics and lipopolysaccharide (LPS, a supramolecule also referred to as endotoxin) from bacterial debris was found that can neutralize the intended function of antibiotics and potentially increase the antibacterial dose. The competition between bacteria and LPS was interrupted by the intervention of a supramolecular trap, helping polymyxin family (e.g. colistin), a last-line antibiotic for defense against invasion by gram-negative bacteria (GNB), to escape being hijacked by LPS. The supramolecular trap fabricated from a subnanometer nanosheet can seal off the active site (lipid A) of LPS to directly interrupt the strong attraction, which can minimize endotoxemia and maximize the colistin activity to achieve greater anti-bacterial efficacy. Thus, the potential crisis of colistin abuse and resistance can potentially be avoided.
    Date: 2020-01
    Relation: Angewandte Chemie. 2020 Jan;59(4):1430-1434.
    Link to: http://dx.doi.org/10.1002/anie.201912137
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1433-7851&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000505914900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078060339
    Appears in Collections:[Shu-Yi Lin] Periodical Articles
    [Shu-Chen Kuo] Periodical Articles

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