國家衛生研究院 NHRI:Item 3990099045/12353
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    题名: Development of a 2-in-1 vaccine for dengue and measles by a recombinant measles virus expressing tetravalent dengue envelope protein domain III
    作者: Pan, CH;Lin, TH;Hsiao, YJ;Yen, JY
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Dengue virus (DENV) infection has a major impact on global public health and current vaccine application is restricted in some countries and only recommended for children older than 9 years. In this study, we have demonstrated that a recombinant measles virus (MV) carried dengue envelope protein domain III (ED3) genes could infect and replicate in the susceptible transgenic mice expressing MV receptor human CD46. After the MV-vectored dengue vaccine immunization, mice developed specific interferon-gamma responses to MV and DENV. Between 4 serotypes of DENV, a dominant DENV-3-specific T-cell response was observed, possibly due to more T-cell epitopes located in DENV-3 ED3 than other serotypes. Neutralizing antibodies against MV and DENV were also induced in the MV-vectored dengue vaccine immunized mice, and protective levels of FRNT50>10 were detected to all serotypes of DENV. We also evaluated the protection against dengue infection. After inoculation with DENV-2, a detectable but significant lower viremia was observed in MV-vectored dengue vaccine immunized mice versus the vector control. In addition, the inflammatory cytokines associated with severe dengue were also significant lower in MV-vectored dengue vaccine immunized mice. Our results with regard to immunogenicity and protection in murine model provide clues for the future application of a 2-in-1 vaccine to against both measles and dengue.
    日期: 2019-10
    關聯: European Journal of Immunology. 2019 Oct;49(S3):1051.
    Link to: https://doi.org/10.1002/eji.201970400
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000490026903276
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