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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12369


    Title: Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment
    Authors: Kaur, N;Fang, YC;Lee, HY;Singh, A;Nepali, K;Lin, MH;Yeh, TK;Lai, MJ;Chan, L;Tu, YK;Banerjee, S;Hu, CJ;Liou, JP
    Contributors: Institute of Biotechnology and Pharmaceutical Research
    Abstract: A series of 10,11-dihydro-5H-dibenzo [b,f]azepine hydroxamates (4-15) were synthesized, behaving as histone deacetylase inhibitors, and examined for their influence on vascular cognitive impairment (VCI), which correlated with dementia. The results revealed that (E)-3-(4-(((3-(3-chloro-10,11-dihydro-5H-dibenzo [b,f]azepin-5-yl)propyl)amino)methyl)phenyl)-N-hydroxy-acrylamide (13) increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy in in vivo study. It is also able to increase the level of histone acetylation (H3K14 or H4K5) in the cortex and hippocampus of chronic cerebral hypoperfusion (CCH) mice; as a result, it could be a potential HDAC inhibitor for the treatment of vascular cognitive impairment.
    Date: 2020-02-01
    Relation: European Journal of Medicinal Chemistry. 2020 Feb 1;187:Article number 111915.
    Link to: http://dx.doi.org/10.1016/j.ejmech.2019.111915
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0223-5234&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000510525000030
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85076133362
    Appears in Collections:[葉燈光] 期刊論文

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