國家衛生研究院 NHRI:Item 3990099045/12385
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12385


    Title: Incidental congestive heart failure in patients with aldosterone-producing adenomas
    Authors: Huang, WC;Chen, YY;Lin, YH;Chen, L;Lin, PC;Lin, YF;Liu, YC;Wu, CH;Chueh, JS;Chu, TS;Wu, KD;Huang, CY;Wu, VC;TAIPAI Study Group
    Contributors: Institute of Population Health Sciences
    Abstract: Background Previous studies show that patients with primary aldosteronism are associated with higher risk of congestive heart failure (CHF). However, the effect of target treatment to the incidental CHF has not been elucidated. We aimed to investigate the risk of new-onset CHF in patients with aldosterone-producing adenomas (APAs) and explore the effect of adrenalectomy on new onset of CHF. Methods and Results From 1997 to 2009, 688 APA were identified and matched with essential hypertension controls. The risks of developing incidental CHF (hazard ratio, 0.49; 95% CI, 0.31-0.75; P=0.001) and mortality (hazard ratio, 0.29; 95% CI, 0.20-0.44; P<0.001) were significantly lower in the APA group after targeted treatment. A total of 605 patients with APAs who underwent adrenalectomy lowered the risks of CHF (subdistribution hazard ratio, 0.55; 95% CI, 0.34-0.90; P=0.017) and mortality (adjusted hazard ratio, 0.27; 95% CI, 0.16-0.44; P<0.001) compared with essential hypertension controls. Conclusions In conclusion, for patients with APAs, adrenalectomy can be associated with lower risk of incidental CHF and all-cause mortality in a long-term follow-up.
    Date: 2019-12-17
    Relation: Journal of the American Heart Association. 2019 Dec 17;8(24):Article number e012410.
    Link to: http://dx.doi.org/10.1161/jaha.119.012410
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2047-9980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000514326200016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077843306
    Appears in Collections:[Li-Kwang Chen] Periodical Articles

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