國家衛生研究院 NHRI:Item 3990099045/12391
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12391


    Title: Predicting lung cancer occurrence in never-smoking females in Asia: TNSF-SQ, a prediction model
    Authors: Chien, LH;Chen, CH;Chen, TY;Chang, GC;Tsai, YH;Hsiao, CF;Chen, KY;Su, WC;Wang, WC;Huang, MS;Chen, YM;Chen, CY;Liang, SK;Chen, CY;Wang, CL;Lee, MH;Chung, RH;Tsai, FY;Hu, JW;Katki, HA;Chatterjee, N;Chanock, SJ;Rothman, N;Lan, Q;Yang, PC;Chen, CJ;Chang, IS;Hsiung, CA
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research
    Abstract: BACKGROUND: High disease burden suggests the desirability to identify high-risk Asian never-smoking females (NSFs) who may benefit from low-dose computed tomography (LDCT) screening. In North America, one is eligible for LDCT screening if one satisfies the U.S. Preventive Services Task Force (USPSTF) criteria or has model-estimated six-year risk >0.0151. According to two US reports, only 36.6% female lung cancer patients met the USPSTF criteria, while 38% of the ever-smokers aged 55-74 met the USPSTF criteria. METHODS: Using data on NSFs in the Taiwan Genetic Epidemiology Study of Lung Adenocarcinoma and the Taiwan Biobank before August 2016, we formed an age-matched case-control study, consisting of 1748 lung cancer patients and 6535 controls. Using these and an estimated age-specific lung cancer six-year incidence rate among Taiwanese NSFs, we developed the Taiwanese NSF Lung Cancer Risk Models using genetic information and simplified questionnaire (TNSF-SQ). Performance evaluation was based on the newer independent datasets: Taiwan Lung Cancer Pharmacogenomics Study (LCPG) and Taiwan Biobank data after August 2016 (TWB2). RESULTS: The AUC based on the NSFs aged 55-70 in LCPG and TWB2 was 0.714 (95% CI 0.660, 0.768). For women in TWB2 aged 55-70, 3.94% (95% CI 2.95, 5.13) had risk higher than 0.0151. For women in LCPG aged 55-74, 27.03% (95% CI 19.04, 36.28) had risk higher than 0.0151. CONCLUSIONS: TNSF-SQ demonstrated good discriminative power. The ability to identify 27.03% of high risk Asian NSFs aged 55-74 deserves attention. IMPACT: TNSF-SQ seems potentially useful in selecting Asian NSFs for LDCT screening.
    Date: 2020-02
    Relation: Cancer Epidemiology, Biomarkers and Prevention. 2020 Feb;29(2):452-459.
    Link to: http://dx.doi.org/10.1158/1055-9965.Epi-19-1221
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1055-9965&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000521285500022
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079075510
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Ren-Hua Chung] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles
    [I-Shou Chang] Periodical Articles

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