國家衛生研究院 NHRI:Item 3990099045/12406
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    题名: Expression and prognostic utility of SSX2IP in patients with nasopharyngeal carcinoma
    作者: Chang, SL;Lee, SW;Yang, SF;Chien, CC;Chan, TC;Chen, TJ;Yang, CC;Li, CF;Wei, YC
    贡献者: National Institute of Cancer Research
    摘要: Cell adhesion affects carcinogenesis, tumor progression, and metastasis. We datamined a published transcriptome (GSE12452) of nasopharyngeal carcinoma (NPC), and identified SSX2IP as a significantly upregulated gene in NPC carcinogenesis among genes associated with cell adhesion (GO:0007155). Consequently, we assessed SSX2IP protein expression and its prognostic significance in 124 patients with NPC using immunohistochemistry and the H-score method. The status of SSX2IP immunoexpression correlated with clinical and pathological characteristics, as well as oncological outcomes. High levels of SSX2IP expression were significantly associated with more advanced primary tumor and TNM stages. Kaplan-Meier and log-rank analyses revealed that high levels of SSX2IP expression, and advanced tumor stage and lymph node metastasis were significantly associated with lower rates of local recurrence-free (LRFS), distant metastasis-free (DMeFS), and disease-specific (DSS) survival. Multivariate analysis showed that high levels of SSX2IP expression significantly predicted DSS (hazard ratio [HR], 4.290; 95% confidence interval [CI], 2.271-8.102; P < 0.001), DMeFS (HR, 4.159' 95% CI, 2.072-8.345; P < 0.001), and LRFS (HR, 3.007' 95% CI,: 1.418-6.378; P = 0.004). We associated high levels of SSX2IP immunoexpression with aggressive pathological features and worse oncological outcomes, suggesting its potential therapeutic value for patients with NPC.
    日期: 2020-04
    關聯: APMIS : Acta Pathologica, Microbiologica, et Immunologica Scandinavica. 2020 Apr;128(4):287-297.
    Link to: http://dx.doi.org/10.1111/apm.13023
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0903-4641&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000509733700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078665360
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