國家衛生研究院 NHRI:Item 3990099045/12415

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12415

Title:	Nanoscopic insights of amphiphilic peptide against the oligomer assembly process to treat Huntington's disease
Authors:	He, RY;Lai, XM;Sun, CS;Kung, TS;Hong, JY;Jheng, YS;Liao, WN;Chen, JK;Liao, YF;Tu, PH;Huang, JJT
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Finding an effective therapeutic regimen is an urgent demand for various neurodegenerative disorders including Huntington's disease (HD). For the difficulties in observing the dynamic aggregation and oligomerization process of mutant Huntingtin (mHtt) in vivo, the evaluation of potential drugs at the molecular protein level is usually restricted. By combing lifetime-based fluorescence microscopies and biophysical tools, it is showcased that a designed amphiphilic peptide, which targets the mHtt at an early stage, can perturb the oligomer assembly process nanoscopically, suppress the amyloid property of mHtt, conformationally transform the oligomers and/or aggregates of mHtt, and ameliorate mHtt-induced neurological damage and aggregation in cell and HD mouse models. It is also found that this amphiphilic peptide is able to transport to the brain and rescue the memory deficit through intranasal administration, indicating its targeting specificity in vivo. In summary, a biophotonic platform is provided to investigate the oligomerization/aggregation process in detail that offers insight into the design and effect of a targeted therapeutic agent for Huntington's disease.
Date:	2020-01-22
Relation:	Advanced Science. 2020 Jan 22;7(2):Article number 1901165.
Link to:	http://dx.doi.org/10.1002/advs.201901165
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2198-3844&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000501479900001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85076363101
Appears in Collections:	[Jen-Kun Chen] Periodical Articles

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