國家衛生研究院 NHRI:Item 3990099045/12467
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12467


    Title: Long-term exposure to ambient hydrocarbons increases dementia risk in people aged 50 years and above in Taiwan
    Authors: Zhang, HW;Kok, VC;Chuang, SC;Tseng, CH;Lin, CT;Li, TC;Sung, FC;Wen, CP;Hsiung, CA;Hsu, CY
    Contributors: Institute of Population Health Sciences
    Abstract: BACKGROUND: Alzheimer's disease, the most common cause of dementia among the elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants is known to have adverse effects on human health, however, little is known about hydrocarbons in the air that can trigger a dementia event. OBJECTIVE: We aimed to investigate whether long-term exposure to airborne hydrocarbons increases the risk of developing dementia. METHOD: The present cohort study included 178,085 people aged 50 years and older in Taiwan. Cox proportional hazards regression analysis was used to fit the multiple pollutant models for two targeted pollutants, including total hydrocarbons and non-methane hydrocarbons, and estimated the risk of dementia. RESULTS: Before controlling for multiple pollutants, hazard ratios with 95% confidence intervals for the overall population were 7.63 (7.28-7.99, p < 0.001) at a 0.51-ppm increases in total hydrocarbons, and 2.94 (2.82-3.05, p < 0.001) at a 0.32- ppm increases in non-methane hydrocarbons. The highest adjusted hazard ratios for different multiple-pollutant models of each targeted pollutant were statistically significant (p < 0.001) for all patients: 11.52 (10.86-12.24) for total hydrocarbons and 9.73 (9.18-10.32) for non-methane hydrocarbons. CONCLUSION: Our findings suggest that total hydrocarbons and non-methane hydrocarbons may be contributing to dementia.
    Date: 2019-01-02
    Relation: Current Alzheimer Research. 2019 Jan 2;16(14):1276-1289.
    Link to: http://dx.doi.org/10.2174/1567205017666200103112443
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1567-2050&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000509869300004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079075253
    Appears in Collections:[Shu-Chun Chuang] Periodical Articles
    [Chi-Pang Wen(2001-2010)] Periodical Articles
    [Chao A. Hsiung] Periodical Articles

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