國家衛生研究院 NHRI:Item 3990099045/12492
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 856897      在线人数 : 953
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12492


    题名: Biomaterials and neural regeneration
    作者: Liu, Y;Hsu, SH
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Neural regeneration is a great clinical challenge in both the central nervous system (CNS) and the peripheral nervous system (PNS). Degeneration in the CNS caused by disease (such as Alzheimer’s or Parkinson’s diseases) or trauma (such as traumatic brain injury and spinal cord injury) often results in permanent paralysis and loss of sensation. The spontaneous neural regeneration in the CNS is generally unsuccessful, while the PNS has an intrinsic regenerative ability. However, PNS regeneration occurs over relatively short distances. Damage to the PNS results in the motor and cognitive impairment in many cases. Biomaterials in the form of scaffolds or nanoparticles for neuroprotection and neuroregeneration have attracted much attention. Nanoparticles can be fabricated using various lipids, polymers, metals, and carbon materials to carry drugs or growth factors. Here, biomaterial scaffolds for neural regeneration are highlighted. Some certain criteria for biomaterial scaffolds in neural regeneration should be met, for example, the biocompatibility for integration with the host tissues, the degradation rates close to the nerve growth, and the mechanical properties similar to the nerve tissue (Hsieh et al., 2015). A number of natural and synthetic polymers have been applied in neural regeneration, including collagen, gelatin, chitosan, alginate, hyaluronan, silk fibroin, poly(L-lactic acid), poly(glycolic acid), polycaprolactone, polyphosphoester, and polyurethane. To improve the bioactivity, conductive biomaterials such as polypyrrole, polythiophene, and polyaniline may enhance neurite outgrowth because electrical signals are transmitted for neuronal communication (Guo and Ma, 2018). Mechanical properties of biomaterial scaffolds can influence neural regeneration, where the soft materials (0.1–1 kPa) promote the neuronal differentiation but the stiffer materials (7–10 kPa) promote the glial differentiation (Tseng et al., 2015). Hydrogel and nerve guide conduit (NGC) are the most frequent choices of scaffolds in CNS and PNS regeneration [Figure 1]A. Moreover, self-healing injectable hydrogel and three-dimensional (3D) printed NGC with unique properties are attractive candidates in each category.
    日期: 2020-07
    關聯: Neural Regeneration Research. 2020 Jul;15(7):1243-1244.
    Link to: http://dx.doi.org/10.4103/1673-5374.272573
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1673-5374&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000507400100008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078193972
    显示于类别:[徐善慧] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB31960803.pdf1068KbAdobe PDF192检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈