國家衛生研究院 NHRI:Item 3990099045/12514
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 956463      線上人數 : 865
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12514


    題名: Arsenic, DNA damage, and cancers of bladder and kidney - a long-term follow-up of residents in arseniasis endemic area of north-eastern Taiwan
    其他題名: Arsenic in the Environment
    作者: Wang, SL;Tsai, SF;Hsu, LI;Chen, CJ;Hsu, KH;Chiou, HY
    貢獻者: National Institute of Environmental Health Sciences
    摘要: The aim is to assess dose-response association between arsenic exposure, DNA damage biomarkers, and the incidence of bladder and kidney cancers. A total of 8102 men and women from 3901 households have been enrolled in 1991-1994, and followed in 2011-2014. The data collected included well water consumption, habits of cigarette smoking, alcohol consumption, exercise and diet, through standardized personal interview. The individual urinary arsenic species were quantified using high-performance liquid chromatography inductively coupled plasma/mass spectrometry (HPLC-ICP/MS). For assessment of oxidative and methylated DNA lesions and depletion, urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) were measured respectively, using liquid chromatography/tandem mass spectrometry (LC-MS/MS). The National Cancer Registry Data using the pathology finding defined bladder and kidney cancers. Urinary levels of the two DNA adduct increased significantly with increasing urinary arsenic level (iAs+MMA+DMA) in both men (beta = 0.82, beta = 0.34 for 8-oxodG and N7-MeG, respectively, p < 0.0001 for both) and women (beta = 1.03, 0.38, p < 0.0001) adjusted for potential confounders. Incidence rate of bladder and kidney cancer using person-years tended to be the highest for higher urinary inorganic and methylated arsenic with higher DNA adduct level than the medians. It is suggested that subjects with high arsenic exposure experienced further cancer risk with high level of DNA damage biomarker.
    日期: 2018-07
    關聯: Environmental Arsenic in a Changing World. 2018 Jul:317-318.
    Link to: https://doi.org/10.1201/9781351046633
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000507999600125
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079212701
    顯示於類別:[王淑麗] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000507999600125.pdf42KbAdobe PDF244檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋