國家衛生研究院 NHRI:Item 3990099045/12534
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12534


    Title: Fission yeast Puf2, a Pumilio and FBF family of RNA-binding protein, links stress granules to processing bodies
    Authors: Hsiao, WY;Wang, YT;Wang, SW
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Stress granules (SGs) are cytoplasmic aggregates formed upon stress when untranslated messenger ribonucleoproteins accumulate in the cells. In a GFP-library screening of the fission yeast SG proteins, Puf2 of the PUF family of RNA-binding proteins was identified that is required for SG formation after deprivation of glucose. Accordingly, puf2 mutant is defective in recovery from glucose starvation with a much longer lag to re-enter the cell cycle. In keeping with these results, Puf2 contains several low-complexity and intrinsically disordered protein regions with a tendency to form aggregates and, when over-expressed, represses translation to induce aggregation of poly(A) binding protein Pabp, the signature constituent of SGs. Intriguingly, over-expression of Puf2 also enhances the structure of processing bodies (PBs), another type of cytoplasmic RNA granules, a complex of factors involved in mRNA degradation. We demonstrate, in this study, a function of the fission yeast PB in SG formation and Puf2 may provide the link of these two structures.
    Date: 2020-05
    Relation: Molecular and Cellular Biology. 2020 May;40(9):Article number e00589-19.
    Link to: http://dx.doi.org/10.1128/mcb.00589-19
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0270-7306&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000526107900004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85083544846
    Appears in Collections:[Shao-Win Wang] Periodical Articles

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