國家衛生研究院 NHRI:Item 3990099045/1258
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    題名: Antitubulin agents for the treatment of cancer - a medicinal chemistry update
    作者: Mahindroo, N;Liou, JP;Chang, JY;Hsieh, HP
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: The antitubulin agents taxanes and Vinca alkaloids form the first-line of treatment in clinical oncology for many cancers. The crucial role of microtubules in cell division has made antitubulin agents the focus of research, with sustained efforts to find new agents and to improve the profile of known agents by overcoming multi-drug resistance (MDR) and improving the druggability. The present review updates the medicinal chemistry of antitubulin agents covering the patents and literature published from May 2002 to November 2005. The antitubulin agents have been broadly classified into microtubule-destabilising agents, microtubule-stabilising agents and kinesin-like spindle protein inhibitors. This review provides an insight into the diversity of the chemical classes with antitubulin mechanisms of anticancer activity.
    關鍵詞: Medicine, Legal;Pharmacology & Pharmacy
    日期: 2006-05
    關聯: Expert Opinion on Therapeutic Patents. 2006 May;16(5):647-691.
    Link to: http://dx.doi.org/10.1517/13543776.16.5.647
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1354-3776&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000237502300005
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33646551448
    顯示於類別:[謝興邦] 期刊論文
    [張俊彥] 期刊論文

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