國家衛生研究院 NHRI:Item 3990099045/12591
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    题名: Management of early stage gastro-oesophageal cancers: Expert perspectives from the Australasian Gastrointestinal Trials Group (AGITG) with invited international faculty
    作者: Roy, AC;Shapiro, J;Burge, M;Karapetis, CS;Pavlakis, N;Segelov, E;Chau, I;Lordick, F;Chen, LT;Barbour, A;Tebbutt, N;Price, T
    贡献者: National Institute of Cancer Research
    摘要: Introduction: A multimodal approach in operable early stage oesophago-gastric (OG) cancer has evolved in the last decade, leading to improvement in overall outcomes.Areas covered: A review of the published literature and conference abstracts was undertaken on the topic of optimal adjunctive chemotherapy or chemoradiotherapy in early stage OG cancers. This review article focuses on the current evidence pertaining to neo-adjuvant and perioperative strategies in curable OG cancers including the evolving landscape of immunotherapy and targeted drugs in this setting.Expert commentary: Adjunctive therapies in the form of pre-operative chemo-radiotherapy (CRT) or chemotherapy and perioperative chemotherapy over surgery alone improves outcomes in patients with operable OG cancer. Although there are variations in practice around the world, a multi-disciplinary approach to patient care is of paramount importance. Immunotherapy and on treatment functional imaging are two examples of emerging strategies to improve outcome for early stage patients. Better understanding of the molecular biology of this disease may help overcome the problem of tumour heterogeneity and enable more rationally designed and targeted therapeutic interventions in the future.
    日期: 2020-04
    關聯: Expert Review of Anticancer Therapy. 2020 Apr;20(4):305-324.
    Link to: http://dx.doi.org/10.1080/14737140.2020.1746185
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1473-7140&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000526683900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85083549325
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