國家衛生研究院 NHRI:Item 3990099045/12608
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    题名: Dishevelled 1-regulated superpotent cancer stem cells mediate wnt heterogeneity and tumor progression in hepatocellular carcinoma
    作者: Liao, WY;Hsu, CC;Chan, TS;Yen, CJ;Chen, WY;Pan, HW;Tsai, KK
    贡献者: National Institute of Cancer Research
    摘要: Various populations of cancer stem cells (CSCs) have been identified in hepatocellular carcinoma (HCC). Wnt signaling is variably activated in HCC and regulates CSCs and tumorigenesis. We explored cell-to-cell Wnt and stemness heterogeneity in HCC by labeling freshly isolated cancer cells with a Wnt-specific reporter, thereby identifying a small subset (0.4%-8.9%) of Wnt-activity(high) cells. Further cellular subset analysis identified a refined subset of Wnt-activity(high)ALDH1(+)EpCAM(+) triple-positive (TP) cells as the most stem-like, phenotypically plastic, and tumorigenic among all putative CSC populations. These TP "superpotent CSCs" (spCSCs) specifically upregulate the expression of dishevelled 1 (DVL1) through the antagonism between abnormal spindle-like microcephaly-associated (ASPM) and the ubiquitin ligase complex Cullin-3/KLHL-12. Subsequent functional and molecular studies revealed the role of DVL1 in controlling spCSCs and their tumorigenic potential. These findings provide the mechanistic basis of the Wnt and stemness heterogeneity in HCC and highlight the important role of DVL1(high) spCSCs in tumor progression.
    日期: 2020-03-10
    關聯: Stem Cell Reports. 2020 Mar 10;14(3):462-477.
    Link to: http://dx.doi.org/10.1016/j.stemcr.2020.02.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2213-6711&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000519777400009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85081654866
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